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The Buffalo Bills have been on a dominant tear in recent weeks, and there’s little to suggest they’ll slow down now. The San Francisco 49ers, meanwhile, are reeling from a wave of injuries that have derailed their season. After starting the year without Christian McCaffrey, he returned just in time for Brock Purdy, Nick Bosa, and Trent Williams to land on the injury list. Even McCaffrey hasn’t looked like his former All-Pro self, failing to surpass 100 rushing yards in any game this season and going three straight games without a touchdown. Meanwhile, Brandon Allen's performance last week against the Packers was uninspiring, as the 49ers managed just 10 points. Nick Bosa is a game-changing edge rusher, and Trent Williams might be the most impactful non-quarterback in the NFL, but their absence or limitations will leave the 49ers vulnerable. The Bills’ defense is poised to pressure either Allen or Purdy, especially with Williams sidelined or less than 100%. Buffalo has won its last five games by at least a touchdown, and in prime time, they’re a strong bet to cover again. Take Buffalo ATS


NFL Football Picks
Sunday, December 1st 2024 8:20 PM
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NFL Football Cappers Picks for San Francisco 49ers vs Buffalo Bills with Cappers winnings percentage for the last 7 days:


Bryan Power 20 % , John Rainey 20 % , Double Dragon 54 % , Randy McKay 43 % , LVSB Total 67 % , Steve Fezzik 67 % , Steve Fezzik 67 % , Dimers 53 % , Mike Tierney 70 % , Stephen Nover 40 % , Liev Jackson 20 % , Jackson Reyes 75 % , Ryan Dodson 54 % , Ryan Dodson 54 % , Ryan Dodson 54 % , Micah Roberts 50 % , Pete Prisco 75 % , Jesse Schule 33 % , Will Brinson 38 % , Porter Picks 42 % , Josh Schonwald 48 % , Duck Investments 40 % , Chris Ruffolo 49 % , Z Code System 46 % , Z Code System 46 % , Chris Jordan 33 % , Adam Silverstein 67 % , R.J. White 100 % , Daniel Vithlani 40 % , Bob Bafle 42 % , HEdge Admin 57 % , Bob Bafle 42 % , James Kaylor 67 % , Bender Wins 43 % , Jake Allmann 42 % , Paul Biagioli 77 % , Chris Macero 0 % , Shane Mickle 47 % , Lenny Stevens 40 % , Northcoast Sports 33 % , Jim Feist 45 % , Chris Ruffolo 49 % , Wayne Root 39 % , Final Score Network 100 % , Jason La Canfora 33 % , James Salinas 29 % , Dquan Picks 56 % , The Champ 53 % , Brad Feinberg 43 % , Raphael Esparza 29 % , Trent Pruitt 59 % , Trent Pruitt 59 % , Weston Stradtman 71 % , Chris Farley 50 % , Ashley Olsen 67 % , Chris Farley 50 % , Sean Higgs 50 % , Timothy Earle 50 % , The Sharp 80 % , Scott Pritchard 71 % , Scott Pritchard 71 % , Tommy G 55 % ,

Spread
Money
Total
6.5 -112
248
O45.5 -110
-6.5 -108
-302
U45.5 -110


SPREAD
San Francisco 49ers 6.5 (-112)
AVG SPREAD W%: 51 ROI: -3
Jackson Reyes W%: 57 ROI: 10 Weston Stradtman W%: 55 ROI: 6 Chris Macero W%: 49 ROI: -7 James Salinas W%: 44 ROI: -17 Scott Pritchard W%: 48 ROI: -9 Randy McKay W%: 49 ROI: -7 Steve Fezzik W%: 54 ROI: -0 Josh Schonwald W%: 49 ROI: -4 Trent Pruitt W%: 51 ROI: -3 Ryan Dodson W%: 50 ROI: -3 Wayne Root W%: 45 ROI: -13 Bender Wins W%: 50 ROI: -9 Lenny Stevens W%: 48 ROI: -9 The Sharp W%: 66 ROI: 28 Bryan Power W%: 50 ROI: -6

SPREAD
Buffalo Bills -6.5 (-108)
AVG SPREAD W%: 50 ROI: -5
Chris Jordan W%: 46 ROI: -11 Jason La Canfora W%: 46 ROI: -8 Pete Prisco W%: 47 ROI: -9 Will Brinson W%: 45 ROI: -15 Z Code System W%: 49 ROI: -4 Micah Roberts W%: 50 ROI: -6 Double Dragon W%: 51 ROI: -4 Chris Ruffolo W%: 50 ROI: -6 Jake Allmann W%: 50 ROI: -7 Paul Biagioli W%: 50 ROI: -3 Shane Mickle W%: 50 ROI: -4 Chris Farley W%: 55 ROI: 5 Final Score Network W%: 57 ROI: 8 Brad Feinberg W%: 47 ROI: -10 Raphael Esparza W%: 49 ROI: -7 Ashley Olsen W%: 47 ROI: -9 Sean Higgs W%: 44 ROI: -14 Jesse Schule W%: 50 ROI: -10 Bob Bafle W%: 51 ROI: -2 Northcoast Sports W%: 50 ROI: -5 Jim Feist W%: 46 ROI: -13 Dquan Picks W%: 49 ROI: -10 The Champ W%: 51 ROI: -7 John Rainey W%: 47 ROI: -11 Liev Jackson W%: 45 ROI: -12 Duck Investments W%: 54 ROI: -4 Adam Silverstein W%: 54 ROI: 2 R.J. White W%: 50 ROI: -4 HEdge Admin W%: 66 ROI: 25 James Kaylor W%: 51 ROI: -6



MONEY
San Francisco 49ers 248
AVG MONEY W%: 50 ROI: -3
Ryan Dodson W%: 50 ROI: -3

MONEY
Buffalo Bills -302
AVG MONEY W%: 50 ROI: -10
Tommy G W%: 50 ROI: -10

TOTAL
UNDER 45.5 (-110)
AVG UNDER W%: 49 ROI: -6
Chris Ruffolo W%: 50 ROI: -6 Trent Pruitt W%: 51 ROI: -3 Chris Farley W%: 55 ROI: 5 Mike Tierney W%: 50 ROI: -5 Ryan Dodson W%: 50 ROI: -3 Porter Picks W%: 50 ROI: -5 LVSB Total W%: 46 ROI: -12 Stephen Nover W%: 48 ROI: -8 Daniel Vithlani W%: 45 ROI: -15

TOTAL
OVER 45.5 (-110)
AVG OVER W%: 49 ROI: -5
Z Code System W%: 49 ROI: -4 Scott Pritchard W%: 48 ROI: -9 Steve Fezzik W%: 54 ROI: -0 Timothy Earle W%: 46 ROI: -10 Dimers W%: 46 ROI: -7 Bob Bafle W%: 51 ROI: -2